voxelotor
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voxelotor

SKU T7581-2 mg Category Brand:

Price range: 53 CAD through 1,418 CAD

Products Details

Product Description

– Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).

Web ID

– T7581

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H19N3O3

Citations

– 1. Shu P, You G, Li W, et al.Cefmetazole sodium as an allosteric effector that regulates the oxygen supply efficiency of adult hemoglobin.Journal of Biomolecular Structure and Dynamics.2023: 1-15.

References

– Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease[J]. Hematology Reports, 2018, 10(2).

CAS Number

– 1446321-46-5

Molecular Weight

– C19H19N3O3

Compound Purity

– 0.9987

SMILES

– CC(C)n1nccc1-c1ncccc1COc1cccc(O)c1C=O

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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