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Volinanserin
Price range: 131 CAD through 1,110 CAD
Products Details
Product Description
– Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma receptors.
Web ID
– T5389
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H28FNO3
Citations
– 1. Zhu H, Liu X, Wang X, et al.Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways.European Journal of Pharmacology.2023: 176038.
2. Gao H, Liu X, Xie L, et al.Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HT2AR-Mediated Gs Signaling Pathway.Neurochemical Research.2023: 1-13.
3. Zhu H, Wang L, Wang X, et al.5-hydroxytryptamine 2C/1A receptors modulate the biphasic dose response of the head twitch response and locomotor activity induced by DOM in mice.Psychopharmacology.2024: 1-16.
References
– Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91.
CAS Number
– 139290-65-6
Molecular Weight
– C22H28FNO3
Compound Purity
– 0.9923
SMILES
– COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC
Pathway
– GPCR/G Protein|||Neuroscience
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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