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VO-Ohpic (trihydrate)
$66 – $682
Products Details
Product Description
– VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC50 of 46±10 nM.
Web ID
– HY-13074
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C12H16N2O11V
Citations
– Biochem Pharmacol. 2020 Jan;171:113715.|Biochem Pharmacol. 2019 Oct;168:82-90. |Biochim Biophys Acta Mol Basis Dis. 25 October 2021, 166292.|BMC Cancer. 2019 Apr 25;19(1):391.|Bone Res. 2018 Nov 10;6:32.|Cancer Med. 2019 Aug;8(9):4265-4277.|Cell Death Dis. 2019 May; 10(5): 329.|Cell Stem Cell. 2022 Apr 7;29(4):545-558.e13.|Clin Transl Med. 2020 Dec;10(8):e240.|Clin Transl Med. 2022 Sep;12(9):e1061.|Environ Sci Technol. 2020 Sep 1;54(17):10783-10796.|Eur Rev Med Pharmacol Sci. 2019 May;23(10):4406-4413.|Int Immunopharmacol. 2021 Dec 23;103:107840.|Int J Mol Med. 2021 Apr 19.|Int J Mol Sci. 2023 Jun 9, 24(12), 9954.|J Cell Mol Med. 2019 Nov;23(11):7535-7544.|Mol Med Rep. 2018 Dec;18(6):5489-5501.|Mol Med Rep. 2022 Jul;26(1):246.|Mol Nutr Food Res. 2019 Dec;63(24):e1900418.|Mol Vis. 2018 Jul 23;24:485-494.|Redox Biol. 2019 Jan;20:390-401. |Stem Cell Res Ther. 2019 Jul 29;10(1):217.|Theranostics. 2019 Jul 9;9(16):4764-4778.|Theranostics. 2019 Jul 9;9(18):5200-5213.|Transl Psychiatry. 2021 Mar 26;11(1):185.|Phytomedicine. 2023 Sep 22, 155117.|SSRN. 2023 Jul 17.
References
– [1]Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic.
J Chem Biol. 2010 Oct;3(4):157-63.|[2]Rosivatz, E, et al. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol. 2006 Dec 15;1(12):780-90.|[3]Zu L, et al. PTEN inhibitors cause a negative inotropic and chronotropic effect in mice.
Eur J Pharmacol. 2011 Jan 10;650(1):298-302.
CAS Number
– 476310-60-8
Molecular Weight
– 415.20
Compound Purity
– 98.0
SMILES
– O[V+2]([N]1=CC=CC(O)=C1C2=O)([O-]2)([O-]C3=CC=CN=C3C4=O)([O-]4)=O.[H+].[3H2O]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL
Target
– Autophagy;PTEN
Pathway
– Autophagy;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
