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Vicriviroc (maleate)
SKU
HY-17377-10 mg
Category Reference compound
Tags Anti-infection;GPCR/G Protein;Immunology/Inflammation, CCR;HIV, Infection; Endocrinology
$231 – $1,892
Products Details
Product Description
– Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).
Web ID
– HY-17377
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C32H42F3N5O6
References
– [1]Tagat JR, et al. Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist. J Med Chem. 2004 May 6;47(10):2405-8.|[2]Strizki JM, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.
CAS Number
– 599179-03-0
Molecular Weight
– 649.70
Compound Purity
– 99.91
SMILES
– CC1(N2C[C@H](C)N([C@H](C3=CC=C(C(F)(F)F)C=C3)COC)CC2)CCN(C(C4=C(C)N=CN=C4C)=O)CC1.O=C(O)/C=CC(O)=O
Clinical Information
– Phase 3
Research Area
– Infection; Endocrinology
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic;warming)
Target
– CCR;HIV
Isoform
– CCR5;HIV-1
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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