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Products Details
Product Description
– VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability[1].
Web ID
– HY-126005
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H32F2N2
References
– [1]Dutta S, et al. Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cells. Bioorg Med Chem. 2018;26(9):2428-2436.
CAS Number
– 2230472-55-4
Molecular Weight
– 386.52
SMILES
– FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCCCN3CCCCC3)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Sodium Channel
Isoform
– Nav1.5
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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