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Products Details
Product Description
– VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells[1].
Web ID
– HY-146230
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H19F3N6O2
References
– [1]Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961.
CAS Number
– 2439096-06-5
Molecular Weight
– 480.44
SMILES
– O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(NC3=C4C=CC=CC4=NC(C(NC)=O)=N3)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
