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Products Details
Product Description
– VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer[1].
Web ID
– HY-151458
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H18ClNO4
References
– [1]Pham EC, et al. Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors. ACS. 2022.
CAS Number
– 2831498-15-6
Molecular Weight
– 371.81
SMILES
– O=C(NCC1=CC=C(Cl)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;Dihydrofolate reductase (DHFR) ;Fungal;VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Anti-infection;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
