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Products Details
Product Description
– Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].
Web ID
– HY-14189
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C30H33Cl4N3O4
References
– [1]Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100.|[2]Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.
CAS Number
– 828271-96-1
Molecular Weight
– 641.41
SMILES
– O=C(OCCN(CC)CC)[C@H](CC1=CC=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=C1)NC(C3=C(C)C=CC=C3Cl)=O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Integrin
Isoform
– α4β1;α4β7
Pathway
– Cytoskeleton
Product type
– Reference compound
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