Val-Cit-PAB-MMAE

$90$620

Products Details

Product Description

– Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

Web ID

– HY-100374

Storage Temperature

– 4°C (Powder, stored under nitrogen)

Shipping

– Room Temperature

Molecular Formula

– C58H94N10O12

References

– [1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

CAS Number

– 644981-35-1

Molecular Weight

– 1123.43

Compound Purity

– 99.83

SMILES

– CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O)=O)C=C3)=O)C)=O)=O)C

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : ≥ 110 mg/mL

Target

– Drug-Linker Conjugates for ADC

Isoform

– Auristatin

Pathway

– Antibody-drug Conjugate/ADC Related

Product type

– ADC Related

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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