Download Files:
Products Details
Product Description
– Ubiquitination-IN-2 is a potent E1-E2 protein−protein interactions (PPI) inhibitor. Ubiquitination-IN-2 has a Kd value of 0.72 μM for ubiquitin E1 (Uba1). Ubiquitination-IN-2 inhibits blocks ubiquitin transfer from E1 to E2. Ubiquitination-IN-2 can be used in research of cancer[1].
Web ID
– HY-152266
Shipping
– Room temperature
Molecular Formula
– C93H173N25O28S8
References
– [1]Zhou L, et, al. Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix. J Med Chem. 2023 Jan 12;66(1):491-502.
Molecular Weight
– 2346.04
SMILES
– O=C(CN(C[C@H](NC(CN(C[C@@H](NC(CN(C[C@H](NC(C)=O)CCCCN)S(=O)(C1=CC=C(C=C1)OC)=O)=O)CCCCNC2=O)S(=O)(C)=O)=O)CCCCN)S(=O)(CCN)=O)N[C@@H](CN(CC(N[C@@H](CN(CC(N[C@@H](CN(CC(N[C@@H](CN(CC(N[C@@H](CN(CC(N)=O)S(=O)(CCN)=O)CC(C)C)=O)S(=O)(C)=O)CCCCN)=O)S(=O)(CC(C)C)=O)CC(C)C)=O)S(=O)(C)=O)CCCCN)=O)S(=O)(C)=O)CCCCNC(C3=CC=C2C=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– E1/E2/E3 Enzyme
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
