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U-46619
$330 – $990
Products Details
Product Description
– U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].
Web ID
– HY-108566
Storage Temperature
– Solution, -20°C, 2 years
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H34O4
References
– [1]Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C–Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117(6):1095-104.|[2]Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9(1):313.|[3]Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR). Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48(6):469-73.|[4]Chen S, et al. Roles of the RhoA-ROCK Signaling Pathway in the Endothelial H2S Production and Vasodilation in Rat Cerebral Arteries. ACS Omega. 2022 May 20;7(22):18498-18508. |[5]Nie D, et al. Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho. Cancer Res. 2008 Jan 1;68(1):115-21.
CAS Number
– 56985-40-1
Molecular Weight
– 350.49
Compound Purity
– 99.0
SMILES
– O=C(O)CCC/C=CC[C@H]1[C@@]2([H])CO[C@@](C2)([H])[C@@H]1/C=C/[C@@H](O)CCCCC
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Prostaglandin Receptor
Isoform
– TXA2/TP
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
