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Products Details
Product Description
– Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC50 of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the cell cycle arrest in the G2/M phase[1].
Web ID
– HY-155314
Shipping
– Room temperature
Molecular Formula
– C24H20FN3O3
References
– [1]Laxmikeshav K et al. Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies [published online ahead of print, 2023 Oct 3]. Bioorg Med Chem Lett. 2023;96:129494.
Molecular Weight
– 417.43
SMILES
– COC1=CC(C2=NC3=C(N2)C=CC(F)=C3)=CC=C1OCC(N4CCC5=C4C=CC=C5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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