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Products Details
Product Description
– Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC50 of 10 nM[1].
Web ID
– HY-155841
Shipping
– Room temperature
Molecular Formula
– C22H25NO6
References
– [1]Wang S, et al. Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells. Pharmaceuticals (Basel). 2023 Jul 13;16(7):1000..
Molecular Weight
– 399.44
SMILES
– O=C1N(C2=CC(OC)=C(OC)C(OC)=C2)[C@@H](C3=CC=C(OC)C(O)=C3)[C@@H]1C(C)=C
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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