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Products Details
Product Description
– TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].
Web ID
– HY-147670
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H9Cl4N5O
References
– [1]Tian N, et al. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo. Bioorg Med Chem. 2020 Aug 15;28(16):115584.
CAS Number
– 2170347-69-8
Molecular Weight
– 453.11
SMILES
– O=C(C1=C(N=C(C=C1)Cl)Cl)NC2=CC(C3=NN=C4C(Cl)=CC=CN43)=C(C=C2)Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Gli;Hedgehog;Smo
Pathway
– Apoptosis;Stem Cell/Wnt
Product type
– Reference compound
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