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Products Details
Product Description
– TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases[1].
Web ID
– HY-148253
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H22N4O3
References
– [1]Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.
CAS Number
– 2095514-75-1
Molecular Weight
– 402.45
SMILES
– O=C1[C@@H](N2CCC3=CN(CC4=CC=CC=C4)N=C3C2=O)COC5=CC=CC=C5N1C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– RIP kinase
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
