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Products Details
Product Description
– Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research[1].
Web ID
– HY-155693
Shipping
– Room temperature
Molecular Formula
– C19H12F4N6O
References
– [1]Srinivasa P S Rao, et al. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023 Jun 30;380(6652):1349-1356.
CAS Number
– 2403729-27-9
Molecular Weight
– 416.33
SMILES
– FC(F)(F)C1=C(C2=CC=C(CN(C(CN3C=NC(C#N)=N3)=O)C4)C4=C2)C=C(F)C=N1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Parasite;Topoisomerase
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
