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TL4-12
$130
Only 1000 item(s) left in stock.
Products Details
Product Description
– TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM)[1].
Web ID
– HY-123714
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H27F3N6O2
References
– [1]Shirong Li, et al. Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma. Blood. 2021 Apr 1;137(13):1754-1764.
CAS Number
– 1620820-12-3
Molecular Weight
– 500.52
Compound Purity
– 99.82
SMILES
– O=C(C1=CC=C(C(OC2=NC=NC(NC)=C2)=C1)C)NC3=CC(C(F)(F)F)=CC(N4CCN(CC4)C)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming)
Target
– Apoptosis;MAP4K
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
