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TKIM
$290 – $790
Products Details
Product Description
– TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1].
Web ID
– HY-134559
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C18H14ClN3O2S
References
– [1]Yuqin Ma, et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. J Med Chem. 2020 Oct 8;63(19):10972-10983.
CAS Number
– 326921-25-9
Molecular Weight
– 371.84
Compound Purity
– 99.73
SMILES
– O=C(NNC(CSC1=NC2=CC=CC=C2C=C1)=O)C3=CC=C(Cl)C=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
