Tiplaxtinin
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Tiplaxtinin

SKU T2030-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 59 CAD through 1,840 CAD

Products Details

Product Description

– Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.

Web ID

– T2030

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H16F3NO4

Citations

– 1. Zhang W, Yang S, Chen D, et al. SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling. Cellular and Molecular Life Sciences. 2022, 79(1): 1-16. 2. Chen X, Wang H, Wu C, et al.Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.Redox Biology.2024: 103038.

References

– Elokdah H, et al. J Med Chem. 2004, 47(14), 3491-3494.

CAS Number

– 393105-53-8

Molecular Weight

– C24H16F3NO4

Compound Purity

– 0.98

SMILES

– OC(=O)C(=O)c1cn(Cc2ccccc2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1

Pathway

– Apoptosis|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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