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Tipiracil
$60 – $240
Products Details
Product Description
– Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
Web ID
– HY-A0063A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H11ClN4O2
Citations
– Oncol Rep. 2023 Mar;49(3):52.|Biomed Pharmacother. 2021 May 6;139:111672.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Mod Rheumatol. 2018 May;28(3):495-505.|Patent. US Patent 11110111.
References
– [1]Lee SJ, et al. Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1327-35.|[2]Raedler LA. Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):97-100.|[3]Tanaka N, et al. Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models. Oncol Rep. 2014 Dec;32(6):2319-26.
CAS Number
– 183204-74-2
Molecular Weight
– 242.66
Compound Purity
– 99.34
SMILES
– O=C1NC(C(Cl)=C(CN2C(CCC2)=N)N1)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic;warming)|H2O : 1 mg/mL (ultrasonic)
Target
– Nucleoside Antimetabolite/Analog;Thymidylate Synthase
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
