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Products Details
Product Description
– TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis[1].
Web ID
– HY-156637
Shipping
– Room temperature
Molecular Formula
– C26H17F4N5O4
References
– [1]Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50(18):4453-70.
CAS Number
– 433224-29-4
Molecular Weight
– 539.44
SMILES
– O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C=C2)OC3=CC4=C(N=C(N4)NC(C5=CC=CO5)=O)C=C3
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Tie;VEGFR
Isoform
– Tie2;VEGFR2/KDR/Flk-1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
