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THX-B
$60 – $500
Products Details
Product Description
– THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders[1][2][3].
Web ID
– HY-137322
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C16H24N6O4
References
– [1]MarÃa Platón-Corchado, et al. p75<sup>NTR</sup> antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa. Cell Death Dis. 2017 Jul 13;8(7):e2922.|[2]Keren Ettinger, et al. Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75<sup>NTR</sup> and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model. Cell Signal. 2012 Dec;24(12):2378-88.|[3]Abubakr H Mossa, et al. Antagonism of proNGF or its receptor p75 NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction. Diabetologia. 2020 Sep;63(9):1932-1946.|[4]Alba Galan, et al. Subconjunctival Delivery of p75NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2852-2862.
CAS Number
– 1372206-64-8
Molecular Weight
– 364.40
Compound Purity
– 98.87
SMILES
– O=C(N(C(C)C)C(NC(C)C)=O)CN1C=NC(N(C)C(N2C)=O)=C1C2=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Neurotensin Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
