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Thioridazine (hydrochloride)
$60 – $96
Products Details
Product Description
– Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].
Web ID
– HY-B0965
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H27ClN2S2
Citations
– Int J Biol Macromol. 25 December 2021.|Pol J Microbiol. 2019 Dec;68(4):477-491.|Int J Mol Sci. 2023, 24(2), 1635.
References
– [1]Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31(3):519-22.|[2]Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31(5):2107-14.|[3]Aguilar-Vega L, et, al. Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii strains. J Appl Microbiol. 2021 Apr 22.|[4]Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17(9):989-97.|[5]Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel). 2021 Apr 23;13(9):2045.
CAS Number
– 130-61-0
Molecular Weight
– 407.04
Compound Purity
– 99.96
SMILES
– CSC(C=C1N2CCC3N(C)CCCC3)=CC=C1SC4=C2C=CC=C4.[H]Cl
Clinical Information
– Launched
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– DMSO : ≥ 45 mg/mL|H2O : 100 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Apoptosis;Autophagy;Bacterial;Dopamine Receptor
Isoform
– 5-HT Receptor
Pathway
– Anti-infection;Apoptosis;Autophagy;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
