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Products Details
Product Description
– TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
Web ID
– T39785
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H21Cl3N8O3
References
– Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250. Published 2018 Jan 17.
CAS Number
– 2253744-57-7
Molecular Weight
– C20H21Cl3N8O3
SMILES
– Cl.Cn1c2nc(N3CCNCC3)n(Cc3nnc(o3)-c3ccc(Cl)c(Cl)c3)c2c(=O)n(C)c1=O
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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