TEPP-46
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TEPP-46

SKU T7214-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 66 CAD through 1,952 CAD

Products Details

Product Description

– TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2) (AC50=92 nM), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity.

Web ID

– T7214

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H16N4O2S2

Citations

– 1. Deng H, Qian X, Zhang Y, et al.Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis.Digestive Diseases and Sciences.2024: 1-15.

References

– Walsh M J , Brimacombe K R , Anastasiou D , et al. ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed, 2009.

CAS Number

– 1221186-53-3

Molecular Weight

– C17H16N4O2S2

Compound Purity

– 0.9847

SMILES

– Cn1c2cc(sc2c2cnn(Cc3cccc(N)c3)c(=O)c12)S(C)=O

Pathway

– Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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