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TC-S 7005
$260 – $1,125
Products Details
Product Description
– TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].
Web ID
– HY-108597
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C21H17N3O3
References
– [1]Stephan Reinhard Künzel, et al. Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation. bioRxiv 445098|[2]Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9.
CAS Number
– 1082739-92-1
Molecular Weight
– 359.38
Compound Purity
– 99.56
SMILES
– C[C@H](NC1=CC2=C(ON=C2C3=CC=C(OCO4)C4=C3)C=N1)C5=CC=CC=C5
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cardiovascular Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Polo-like Kinase (PLK)
Isoform
– PLK1;PLK2;PLK3
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
