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Products Details
Product Description
– Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant
protective effects in LPS-induced acute lung injury in mice[1][2].
Web ID
– HY-N12042
Shipping
– Room temperature
Molecular Formula
– C22H24O4
References
– [1]Liu M, et al. Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-κB axis in macrophages. Eur J Med Chem. 2023 Nov 15;260:115769.|[2]Liang JY, et al. Two new antineoplastic diterpenes from Taxus mairei. Chem Pharm Bull (Tokyo). 1987 Jun;35(6):2613-4.
CAS Number
– 110300-77-1
Molecular Weight
– 352.42
SMILES
– CC(C1=C2)(C)C(C=CC1=CC3=C(C=C(C(C)C)C(OC)=C3OC)C2=O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Interleukin Related;PI3K;Reactive Oxygen Species;TNF Receptor
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
Product type
– Reference compound
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