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Products Details
Product Description
– Tasimelteon-d5 is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)[1][2].
Web ID
– HY-14803S
Shipping
– Room temperature
Molecular Formula
– C15H14D5NO2
References
– [1]Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7.|[2]Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1962124-51-1
Molecular Weight
– 250.35
SMILES
– [H][C@]1(C[C@H]1CNC(C([2H])(C([2H])([2H])[2H])[2H])=O)C2=C3CCOC3=CC=C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Melatonin Receptor
Isoform
– MT2
Pathway
– GPCR/G Protein;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
