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TAS6417
Price range: 142 CAD through 5,248 CAD
Products Details
Product Description
– Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor that uniquely binds to the ATP binding site of the EGFR hinge region with an IC50 value of 1.1-8.0 nM.
Web ID
– T16996
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C23H20N6O
Citations
– 1. Liang J, Bi G, Sui Q, et al.Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.Cell Reports.2024, 43(2).
References
– Hasako S, et al. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17(8):1648-1658.
CAS Number
– 1661854-97-2
Molecular Weight
– C23H20N6O
Compound Purity
– 0.9971
SMILES
– CC1=C[C@@H](Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc21)NC(=O)C=C
Target
– Others
Pathway
– Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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