TAK-243
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TAK-243

SKU T16974-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 66 CAD through 1,109 CAD

Products Details

Product Description

– TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.

Web ID

– T16974

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H20F3N5O5S2

Citations

– 1. Wang Y, Yang H, Li N, et al.A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of NaV1. 2 Sodium Channels.Advanced Science.2024: 2400560. 2. Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders

References

– Zhuang J, et al. Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma. Blood. 2019 Apr 4;133(14):1572-1584.

CAS Number

– 1450833-55-2

Molecular Weight

– C19H20F3N5O5S2

Compound Purity

– 0.9882

SMILES

– NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O

Target

– Tyrosinase|||EGFR

Pathway

– Apoptosis|||Ubiquitination|||NF-κB

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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