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SZM-1209
SKU
HY-149052-Get quote
Category Reference compound
Tags Apoptosis;MAPK/ERK Pathway, Inflammation/Immunology, Mixed Lineage Kinase;Necroptosis;RIP kinase
Products Details
Product Description
– SZM-1209 is an orally active, potent and specific RIPK1 inhibitor, with a Kd of 85 nM. SZM-1209 exhibits high anti-necroptotic activity (EC50=22.4 ± 8.1 nM). SZM-1209 shows anti-SIRS (systemic inflammatory response syndrome), and anti-ALI (acute lung injury) effects[1].
Web ID
– HY-149052
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H29F5N4O5S2
References
– [1]Zhang X, et al. Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway. J Med Chem. 2023 Apr 13;66(7):5261-5278.
CAS Number
– 2919801-86-6
Molecular Weight
– 696.71
SMILES
– CCS(=O)(NC1CCC(CC1)C(NC2=NC3=C(S2)C=C(C(F)=C3)OC4=CC=C(C(NC(CC5=CC=CC(C(F)(F)F)=C5)=O)=C4)F)=O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Mixed Lineage Kinase;Necroptosis;RIP kinase
Isoform
– RIPK1;RIPK3
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.