Sunitinib
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Sunitinib

SKU T0374L-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 222 CAD

Products Details

Product Description

– Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). It exhibits antitumor activity and is used for treating kidney cancer and gastrointestinal tumors.

Web ID

– T0374L

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H27FN4O2

Citations

– 1. Wang C, Huang M, Lin Y, et al.ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy.Nature Metabolism.2023: 1-22. 2. Oeller M, Jaksch-Bogensperger H, Templin M, et al.Transcription Factors STAT3 and MYC Are Key Players of Human Platelet Lysate-Induced Cell Proliferation.International Journal of Molecular Sciences.2022, 23(24): 15782. 3. Xue K H, Jiang Y F, Bai J Y, et al.Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect.Redox Report.2023, 28(1): 2251234. 4. Liu T, Yue X, Chen X, et al.Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma.Cellular Oncology.2024: 1-18. 5. Dai Y, Li H, Fan S, et al.Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma.Cell Death & Disease.2025, 16(1): 1-12. 6. Machine learning–enabled virtual screening indicates the anti-tuberculosis activity of aldoxorubicin and quarfloxin with verification by molecular docking, molecular dynamics simulations, and biological evaluations

References

– O’Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605.

CAS Number

– 557795-19-4

Molecular Weight

– C22H27FN4O2

Compound Purity

– 0.9822

SMILES

– C(=C1/C=2C(NC1=O)=CC=C(F)C2)C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3

Target

– Others

Pathway

– Cell Cycle/Checkpoint|||Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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