Sulfaphenazole
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Sulfaphenazole

SKU T4567-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 77 CAD through 80 CAD

Products Details

Product Description

– Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

Web ID

– T4567

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H14N4O2S

References

– Annah Mancy, et al. Interaction of Sulfaphenazole Derivatives with Human Liver Cytochromes P450 2C:  Molecular Origin of the Specific Inhibitory Effects of Sulfaphenazole on CYP 2C9 and Consequences for the Substrate Binding Site Topology of CYP 2C9[J]. Biochemistry, 1996, 35(50):16205.

CAS Number

– 526-08-9

Molecular Weight

– C15H14N4O2S

Compound Purity

– 0.9883

SMILES

– NC1=CC=C(C=C1)S(=O)(=O)NC1=CC=NN1C1=CC=CC=C1

Pathway

– Microbiology/Virology|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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