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Staurosporine
Price range: 90 CAD through 2,160 CAD
Products Details
Product Description
– Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.
Web ID
– T6680
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H26N4O3
Citations
– 1. Lü Z, Li X, Li K, et al. Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes. Biochemical Pharmacology. 2022: 114913.
2. Yang G, Wan P, Xiang Q, et al. E3 Ubiquitin Ligase ASB17 Promotes Apoptosis by Ubiquitylating and Degrading BCLW and MCL1. Biology-Basel. 2021, 10(3): 234.
3. Yang J B, Song Y F, Liu Y, et al. UHPLC-QQQ-MS/MS assay for quantification of dianthrones as potential toxic markers of Polygonum multiflorum Thunb: Application to the standardization of TCMs with endogenous toxicity. Chinese Medicine. 021 Jul 3;16(1):51. doi: 10.1186/s13020-021-00463-w.
4. Xiao Q, Ye T, Wang X, et al. A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer’s disease. Experimental Gerontology. 2021 Jul 1;149:111336. doi: 10.1016/j.exger.2021.111336. Epub 2021 Mar 27.
5. Jiang X, Teng X, Shi H, et al.Discovery and optimization of olanzapine derivatives as new ferroptosis inhibitors.Bioorganic Chemistry.2023: 106393.
6. Liu H, Chen M, Ning F, et al.Extravillous trophoblast cell derived exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR-143-3p.Molecular Human Reproduction.2023: gaad026.
7. Tschuck J, Theilacker L, Rothenaigner I, et al.Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis.Nature Communications.2023, 14(1): 6908.
8. Tan Q, Wu D, Lin Y, et al.Identifying eleven new ferroptosis inhibitors as neuroprotective agents from FDA-approved drugs.Bioorganic Chemistry.2024: 107261.
9. Sicinska E, Kola V S R, Kerfoot J A, et al.ASPSCR1:: TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs.Cancer Research.2024
10. Xu X, Lu Y, Cao L, et al.Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production.Cell Reports.2024, 43(7): 114469.
References
– Ma X, et al. Staurosporine targets the Hippo pathway to inhibit cell growth. J Mol Cell Biol. 2018 Jun 1;10(3):267-269.
CAS Number
– 62996-74-1
Molecular Weight
– C28H26N4O3
Compound Purity
– 0.9987
SMILES
– CN[C@H]1C[C@@H]2O[C@@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Pathway
– Angiogenesis|||Chromatin/Epigenetic|||Apoptosis|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Microbiology/Virology
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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