Spautin-1
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Spautin-1

SKU T1937-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 590 CAD

Products Details

Product Description

– Spautin-1 is an autophagy inhibitor that suppresses the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Spautin-1 inhibits UPR and exhibits preferential cytotoxicity in glucose-starved cancer cells.

Web ID

– T1937

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H11F2N3

Citations

– 1. Wu W, Xu H, Liao C, et al. Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination. Cellular Oncology. 2022: 1-15 2. Yuan T, Chen Z, Yan F, et al. Deubiquitinating Enzyme USP10 Promotes Hepatocellular Carcinoma Metastasis through Deubiquitinating and Stabilizing Smad4 Protein. Molecular Oncology. 2020, 14(1): 197-210 3. Yue X, Liu T, Wang X, et al.Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.Acta Pharmaceutica Sinica B.2023 4. Xu X, Xie T, Zhou M, et al.Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation.Nature Communications.2024, 15(1): 4237.

References

– Liu J, et al. Cell. 2011, 147(1), 223-234.

CAS Number

– 1262888-28-7

Molecular Weight

– C15H11F2N3

Compound Purity

– 0.9899

SMILES

– Fc1ccc(CNc2ncnc3ccc(F)cc23)cc1

Target

– Others

Pathway

– Cell Cycle/Checkpoint|||Apoptosis|||DNA Damage/DNA Repair|||Autophagy|||Ubiquitination

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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