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Products Details
Product Description
– Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold[1][2].
Web ID
– HY-120994B
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16H15ClN5O5PS2
References
– [1]Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3′,5′-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91.|[2]Boese M, et, al. Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. Br J Pharmacol. 1996 Oct;119(4):707-15.|[3]Spicuzza L, et, al. Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol. 2001 Aug;133(8):1201-12.
CAS Number
– 129693-13-6
Molecular Weight
– 487.88
SMILES
– O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S)=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– PKA
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
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