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Products Details
Product Description
– Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].
Web ID
– HY-137638
Shipping
– Room temperature
Molecular Formula
– C12H11Cl2N2O5PS
References
– [1]Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3′,5′-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7.|[2]Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3′,5′-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22.|[3]Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13.
CAS Number
– 120912-54-1
Molecular Weight
– 397.17
SMILES
– O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S)=O)([H])N(C=NC3=C4)C3=CC(Cl)=C4Cl
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– PKA
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
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