Download Files:
SP-100030
Price range: 48 CAD through 914 CAD
Products Details
Product Description
– SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA).
Web ID
– T24816
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H5ClF9N3O
References
– Sullivan RW, et al. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3′,5′- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem. 1998;4
CAS Number
– 154563-54-9
Molecular Weight
– C14H5ClF9N3O
Compound Purity
– 0.9957
SMILES
– C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(=O)C=2C(C(F)(F)F)=NC(Cl)=NC2
Pathway
– NF-κB
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
