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Sofosbuvir
$55 – $209
Products Details
Product Description
– Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM[1].
Web ID
– HY-15005
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C22H29FN3O9P
References
– [1]Murakami E, et al.
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47.|[2]Sofia MJ, et al. Discovery of a β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18.|[3]Lam AM, et al.
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.|[4]Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.
CAS Number
– 1190307-88-0
Molecular Weight
– 529.45
Compound Purity
– 99.99
SMILES
– C[C@@]1(F)[C@H](O)[C@@H](CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)O[C@H]1N(C=CC(N3)=O)C3=O
Clinical Information
– Launched
Research Area
– Infection
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic;warming;heat to 50°C)
Target
– HCV
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
