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Products Details
Product Description
– Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].
Web ID
– HY-149316
Shipping
– Room temperature
Molecular Formula
– C24H29ClN6O2
References
– [1]Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139.
CAS Number
– 1824708-03-3
Molecular Weight
– 468.98
SMILES
– O=C(C1=C(C)N(C2=CC=C(C3CC3)C=C2Cl)N=N1)NC4=C(C)N(C)N(C5CCCCC5)C4=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– E1/E2/E3 Enzyme
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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