SMS2-IN-2
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SMS2-IN-2

SKU T7263-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 186 CAD through 2,224 CAD

Products Details

Product Description

– SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

Web ID

– T7263

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H13ClFN3O2

Citations

– 1. Liang H, Ma X, Zhang Y, et al.The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells.Nature Cell Biology.2023: 1-12.

References

– Mo M, Yang J, Jiang XC,et al.Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice[J].J Med Chem. 2018 Sep 27;61(18):8241-8254.

CAS Number

– 2241838-28-6

Molecular Weight

– C19H13ClFN3O2

Compound Purity

– 0.98

SMILES

– Fc1ccc(Cl)c(COc2cccc3onc(Nc4cccnc4)c23)c1

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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