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Skp2 inhibitor 2
$300 – $2,400
Products Details
Product Description
– Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].
Web ID
– HY-153937
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Molecular Formula
– C27H32N4O
References
– [1]Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.
CAS Number
– 2760612-77-7
Molecular Weight
– 428.57
Compound Purity
– 99.67
SMILES
– O=C(C(C)(C)C)NCC1CCN(CC1)C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 12 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– E1/E2/E3 Enzyme
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
