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SKI-178
Price range: 66 CAD through 1,872 CAD
Products Details
Product Description
– SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Web ID
– T9014
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H22N4O4
References
– Hengst JA, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Transl Med. 2017;3(4):109-121.
CAS Number
– 1259484-97-3
Molecular Weight
– C21H22N4O4
Compound Purity
– 0.992
SMILES
– COc1ccc(cc1)-c1cc([nH]n1)C(=O)NN=C(/C)c1ccc(OC)c(OC)c1
Pathway
– Apoptosis|||GPCR/G Protein
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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