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Products Details
Product Description
– SJ10542, a phenyl glutarimide (PG)-PROTAC, demonstrates potent and selective activity against JAK2/3 by exhibiting DC50 values of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. It employs a PG ligand for cereblon (CRBN) recruitment [1].
Web ID
– T74429
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C41H46N12O5S
CAS Number
– 2789678-92-6
Molecular Weight
– C41H46N12O5S
SMILES
– C(C#N)C1(CN(S(CC)(=O)=O)C1)N2C=C(C=N2)C3=C4C(=NC(NC5=CC=C(C(NCCCN6CCN(CC6)C7=CC=C(C=C7)C8C(=O)NC(=O)CC8)=O)C=C5)=N3)NC=C4
Pathway
– PROTAC
Product type
– PROTAC
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