Sivopixant
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Sivopixant

SKU T40045-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 142 CAD through 1,952 CAD

Products Details

Product Description

– Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .

Web ID

– T40045

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H22ClN5O5

Citations

– 1. Wang D P, Zhang M, Li M, et al.Druggable site near the upper vestibule determines the high affinity and P2X3 homotrimer selectivity of Sivopixant/S‐600918 and its analogue DDTPA.British Journal of Pharmacology.2023

References

– Kai H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists [published online ahead of print, 2021 Sep 26]. Bioorg Med Chem Lett. 2021;52:128384.

CAS Number

– 2414285-40-6

Molecular Weight

– C25H22ClN5O5

Compound Purity

– 0.9921

SMILES

– C(N1C(=NC2=CC=C(OC3=CC=CC=N3)C=C2)NC(=O)N(C[C@@H](C(O)=O)C)C1=O)C4=CC=C(Cl)C=C4

Pathway

– Neuroscience|||Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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