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Siramesine (hydrochloride)
$70 – $1,180
Products Details
Product Description
– Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
Web ID
– HY-14221A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H32ClFN2O
Citations
– Patent. US20220305013A1.|Adv Sci (Weinh). 2023 Mar 11;e2300311.|Dean Francis. 2023 Jun.|J Pharmacol Exp Ther. 2015 Aug;354(2):203-12.
CAS Number
– 224177-60-0
Molecular Weight
– 491.04
Compound Purity
– 99.74
SMILES
– FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 42 mg/mL
Target
– Ferroptosis;Sigma Receptor
Isoform
– Sigma 1 Receptor
Pathway
– Apoptosis;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
