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Sildenafil-d8
$520 – $1,563
Products Details
Product Description
– Sildenafil-d8 is the deuterium labeled Sildenafil. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM[1][2].
Web ID
– HY-15025S1
Shipping
– Room temperature
Molecular Formula
– C22H22D8N6O4S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95.|[3]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11.|[4]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7.|[5]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40.
CAS Number
– 951385-68-5
Molecular Weight
– 482.63
SMILES
– O=C1C(N(C)N=C2CCC)=C2NC(C3=CC(S(=O)(N4C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C4([2H])[2H])=O)=CC=C3OCC)=N1
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Isotope-Labeled Compounds;Phosphodiesterase (PDE)
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
