SID 26681509 (quarterhydrate)

$195$980

Products Details

Product Description

– SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G[1].

Web ID

– HY-103353A

Storage Temperature

– -20°C, 3 years (Powder)

Shipping

– Blue Ice

Applications

– COVID-19-immunoregulation

Molecular Formula

– C27H33N5O5S.1/4H2O

Citations

– Signal Transduct Target Ther. 2023 Oct 11;8(1):390.|Nat Commun. 2020 Mar 27;11(1):1620.|Nat Commun. 2022 May 26;13(1):2935.|Signal Transduct Target Ther. 2021 Mar 27;6(1):134.

References

– [1]Shah PP, et al. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol. 2008 Jul;74(1):34-41.|[2]Pribis JP, et al. The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88. Mol Med. 2015 Dec;21(1):749-757.

Molecular Weight

– 544.16

Compound Purity

– 97.0

SMILES

– O=C(NNC(SCC(NC1=CC=CC=C1CC)=O)=O)[C@H](CC2=CNC3=CC=CC=C23)NC(OC(C)(C)C)=O.[1/4].O

Clinical Information

– No Development Reported

Research Area

– Cancer; Infection

Solubility

– DMSO : 50 mg/mL (ultrasonic)|Ethanol : 5 mg/mL (ultrasonic;warming)

Target

– Cathepsin;Parasite

Isoform

– Cathepsin L;Leishmania;Plasmodium

Pathway

– Anti-infection;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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