Shogaol
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Shogaol

SKU T6S1699-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 58 CAD through 1,579 CAD

Products Details

Product Description

– 1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats. 3. 6-Shogaol inhibits the growth of human cancer cells and induces apoptosis in COLO 25 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). 4. 6-Shogaol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis, could further regulate urokinase-type plasminogen activity.

Web ID

– T6S1699

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H24O3

Citations

– 1. Zhang B, Zhao J, Wang Z, et al. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Frontiers in Pharmacology. 2021：1781 2. Kamaruddin M S H, Chong G H, Umanan F, et al.Enhancement of 6-gingerol extraction from Bentong ginger using supercritical carbon dioxide.Journal of CO2 Utilization.2023, 72: 102505.

References

– Han M A , Woo S M , Min K J , et al. 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression[J]. Chem Biol Interact, 2015, 228:69-78.

CAS Number

– 555-66-8

Molecular Weight

– C17H24O3

Compound Purity

– 0.9939

SMILES

– CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1

Pathway

– Metabolism|||Autophagy

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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