SG3199

$850$3,750

Products Details

Product Description

– SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)[1][2].

Web ID

– HY-101161

Storage Temperature

– -20°C (Powder, protect from light, stored under nitrogen)

Shipping

– Blue Ice

Applications

– Cancer-programmed cell death

Molecular Formula

– C33H36N4O6

References

– [1]John A Hartley, et al. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. Sci Rep. 2018 Jul 11;8(1):10479.|[2]Francesca Zammarchi, et al. ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies. Blood. 2018 Mar 8;131(10):1094-1105.

CAS Number

– 1595275-71-0

Molecular Weight

– 584.66

Compound Purity

– 98.94

SMILES

– O=C1N2[C@](CC(C)=C2)([H])C=NC3=CC(OCCCCCOC4=C(OC)C=C5C(N6[C@](CC(C)=C6)([H])C=NC5=C4)=O)=C(OC)C=C13

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 130 mg/mL (ultrasonic)

Target

– ADC Cytotoxin;DNA Alkylator/Crosslinker

Isoform

– Pyrrolobenzodiazepines

Pathway

– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage

Product type

– ADC Related

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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